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Gene Symbol |
NPY1R |
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Aliases |
NPY1-R, NPYR |
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Entrez Gene ID |
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Gene Name |
Neuropeptide Y receptor Y1 |
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Chromosomal Location |
4q32.2 |
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HGNC ID |
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Summary |
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
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e!Ensembl
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SNPs
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SNP |
SNP ID |
Associated disease |
References |
| K374T |
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Gonadotropin-dependent precocious puberty (GDPP) |
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Gene Ontology (GO)
| GO ID |
Ontology |
Function |
Evidence |
Reference |
| GO:0003151 |
Biological process |
Outflow tract morphogenesis |
IMP |
19593212 |
| GO:0007187 |
Biological process |
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
TAS |
1317848 |
| GO:0007193 |
Biological process |
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
TAS |
1321422 |
| GO:0005887 |
Cellular component |
Integral component of plasma membrane |
TAS |
1317848 |
| GO:0001602 |
Molecular function |
Pancreatic polypeptide receptor activity |
IBA |
21873635 |
| GO:0004983 |
Molecular function |
Neuropeptide Y receptor activity |
TAS |
1317848 |
| GO:0005515 |
Molecular function |
Protein binding |
IPI |
23597562 |
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| Protein Information |
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Protein Name |
Neuropeptide Y receptor type 1 |
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Function |
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Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid |
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UniProt |
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PDB |
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