Enrichment analyses of diseases and pathways associated with precocious puberty using PrecocityDB

Gene Information

Gene Symbol

PROKR2

Aliases

GPR73L1, GPR73b, GPRg2, HH3, KAL3, PKR2, dJ680N4.3

Entrez Gene ID

128674

Gene Name

Prokineticin receptor 2

Chromosomal Location

20p12.3

HGNC ID

15836

Summary

Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_008132.2

RefSeq mRNA

NM_144773.3, NM_144773.4

e!Ensembl

Gene	ENSG00000101292
Transcript	ENST00000217270
Protein	ENSP00000217270

SNPs

SNP	SNP ID	Associated disease	References
c.724_727delTGCT		Central Precocious Puberty (CPP)	28338294
C242fsX305		Central Precocious Puberty (CPP)	28338294

Gene Ontology (GO)

Show/Hide all(6 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007186	Biological process	G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007623	Biological process	Circadian rhythm	IBA	21873635
GO:0005886	Cellular component	Plasma membrane	IDA	18826963
GO:0005887	Cellular component	Integral component of plasma membrane	IBA	21873635
GO:0004930	Molecular function	G protein-coupled receptor activity	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	32296183

Protein Information

Protein Name

Prokineticin receptor 2, G protein-coupled receptor 73-like 1, G-protein coupled receptor I5E, PK-R2

Function

Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase

Refseq Proteins

NP_658986.1

UniProt

Q8NFJ6