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Gene Symbol |
TNFAIP6 |
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Aliases |
TSG-6, TSG6 |
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Entrez Gene ID |
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Gene Name |
TNF alpha induced protein 6 |
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Chromosomal Location |
2q23.3 |
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HGNC ID |
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Summary |
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]
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e!Ensembl
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| Protein Information |
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Protein Name |
Tumor necrosis factor-inducible gene 6 protein, TNF-stimulated gene 6 protein, hyaluronate-binding protein, tumor necrosis factor alpha-inducible protein 6, tumor necrosis factor, alpha induced protein 6, tumor necrosis factor-stimulated gene-6 protein |
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Function |
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Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis |
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UniProt |
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PDB |
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