Enrichment analyses of diseases and pathways associated with precocious puberty using PrecocityDB

Gene Information

Gene Symbol

INS

Aliases

IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10, PNDM4

Entrez Gene ID

3630

Gene Name

Insulin

Chromosomal Location

11p15.5

HGNC ID

6081

RefSeq DNA

NG_007114.1

RefSeq mRNA

NM_000207.3, NM_001185097.2, NM_001185098.2, NM_001291897.2

e!Ensembl

Gene	ENSG00000254647
Transcript	ENST00000397262, ENST00000250971, ENST00000381330, ENST00000421783, ENST00000512523
Protein	ENSP00000380432, ENSP00000250971, ENSP00000370731, ENSP00000408400, ENSP00000424008

Gene Ontology (GO)

Show/Hide all(75 )

GO ID	Ontology	Function	Evidence	Reference
GO:0002674	Biological process	Negative regulation of acute inflammatory response	IDA	11443198
GO:0006355	Biological process	Regulation of transcription, DNA-templated	NAS	12881524
GO:0006521	Biological process	Regulation of cellular amino acid metabolic process	IMP	3553851
GO:0006953	Biological process	Acute-phase response	IDA	14739855
GO:0007186	Biological process	G protein-coupled receptor signaling pathway	IDA	9092559
GO:0007267	Biological process	Cell-cell signaling	IC	7556975
GO:0008284	Biological process	Positive regulation of cell proliferation	IDA	7688386, 17925406
GO:0008286	Biological process	Insulin receptor signaling pathway	IDA	20455999
GO:0010628	Biological process	Positive regulation of gene expression	IGI	25403480
GO:0010750	Biological process	Positive regulation of nitric oxide mediated signal transduction	IDA	15792832
GO:0010750	Biological process	Positive regulation of nitric oxide mediated signal transduction	IMP	14615391
GO:0014068	Biological process	Positive regulation of phosphatidylinositol 3-kinase signaling	IDA	7688386
GO:0022898	Biological process	Regulation of transmembrane transporter activity	IDA	14615391
GO:0030307	Biological process	Positive regulation of cell growth	NAS	11742412
GO:0030335	Biological process	Positive regulation of cell migration	ISS	12138094
GO:0031954	Biological process	Positive regulation of protein autophosphorylation	ISS	3518947
GO:0032148	Biological process	Activation of protein kinase B activity	IDA	8702995
GO:0032270	Biological process	Positive regulation of cellular protein metabolic process	IMP	3553851
GO:0032880	Biological process	Regulation of protein localization	IDA	14615391
GO:0033861	Biological process	Negative regulation of NAD(P)H oxidase activity	IDA	11443198
GO:0042060	Biological process	Wound healing	IDA	9498508
GO:0042177	Biological process	Negative regulation of protein catabolic process	IDA	15185208
GO:0042593	Biological process	Glucose homeostasis	IMP	381941
GO:0043410	Biological process	Positive regulation of MAPK cascade	IDA	11500939, 20455999
GO:0045597	Biological process	Positive regulation of cell differentiation	NAS	11742412
GO:0045721	Biological process	Negative regulation of gluconeogenesis	NAS	11742412
GO:0045725	Biological process	Positive regulation of glycogen biosynthetic process	IDA	17925406
GO:0045818	Biological process	Negative regulation of glycogen catabolic process	IMP	381941
GO:0045821	Biological process	Positive regulation of glycolytic process	IDA	7688386
GO:0045821	Biological process	Positive regulation of glycolytic process	IMP	381941
GO:0045840	Biological process	Positive regulation of mitotic nuclear division	IDA	10644978, 11500939
GO:0045861	Biological process	Negative regulation of proteolysis	IMP	3553851
GO:0045922	Biological process	Negative regulation of fatty acid metabolic process	IMP	1184755
GO:0046326	Biological process	Positive regulation of glucose import	IDA	14615391, 15792832
GO:0046326	Biological process	Positive regulation of glucose import	IMP	14615391
GO:0046628	Biological process	Positive regulation of insulin receptor signaling pathway	IDA	7688386, 15792832
GO:0046628	Biological process	Positive regulation of insulin receptor signaling pathway	IMP	14615391
GO:0046631	Biological process	Alpha-beta T cell activation	IDA	10604997
GO:0046889	Biological process	Positive regulation of lipid biosynthetic process	NAS	11742412
GO:0048167	Biological process	Regulation of synaptic plasticity	TAS	19188609
GO:0050708	Biological process	Regulation of protein secretion	IDA	15591776
GO:0050709	Biological process	Negative regulation of protein secretion	IDA	14739855
GO:0050715	Biological process	Positive regulation of cytokine secretion	IDA	15473891
GO:0050890	Biological process	Cognition	TAS	19188609
GO:0050995	Biological process	Negative regulation of lipid catabolic process	IMP	24675707
GO:0050995	Biological process	Negative regulation of lipid catabolic process	NAS	11742412
GO:0051000	Biological process	Positive regulation of nitric-oxide synthase activity	NAS	12135947
GO:0051092	Biological process	Positive regulation of NF-kappaB transcription factor activity	IDA	19727662
GO:0051897	Biological process	Positive regulation of protein kinase B signaling	IDA	11500939
GO:0055089	Biological process	Fatty acid homeostasis	IMP	1184755
GO:0060266	Biological process	Negative regulation of respiratory burst involved in inflammatory response	IDA	11443198
GO:0060267	Biological process	Positive regulation of respiratory burst	IDA	9092559
GO:0090277	Biological process	Positive regulation of peptide hormone secretion	TAS	11387233
GO:0090336	Biological process	Positive regulation of brown fat cell differentiation	TAS	11387233
GO:0097755	Biological process	Positive regulation of blood vessel diameter	NAS	14744991
GO:0097756	Biological process	Negative regulation of blood vessel diameter	NAS	12946932
GO:1900182	Biological process	Positive regulation of protein localization to nucleus	IDA	20455999
GO:1900273	Biological process	Positive regulation of long-term synaptic potentiation	TAS	19188609
GO:1902176	Biological process	Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	NAS	16604263
GO:1902952	Biological process	Positive regulation of dendritic spine maintenance	IGI	19188609
GO:1903076	Biological process	Regulation of protein localization to plasma membrane	IGI	19188609
GO:1903427	Biological process	Negative regulation of reactive oxygen species biosynthetic process	IGI	19188609
GO:1990535	Biological process	Neuron projection maintenance	IGI	19188609
GO:2000252	Biological process	Negative regulation of feeding behavior	IDA	17957153
GO:0005576	Cellular component	Extracellular region	IC	7556975
GO:0005615	Cellular component	Extracellular space	IDA	9667398
GO:0002020	Molecular function	Protease binding	IPI	20082125
GO:0005158	Molecular function	Insulin receptor binding	IDA	7556975, 9667398
GO:0005158	Molecular function	Insulin receptor binding	IPI	8452530
GO:0005159	Molecular function	Insulin-like growth factor receptor binding	IPI	8452530
GO:0005179	Molecular function	Hormone activity	IC	9667398
GO:0005179	Molecular function	Hormone activity	IMP	381941
GO:0005179	Molecular function	Hormone activity	NAS	14986111
GO:0005515	Molecular function	Protein binding	IPI	9388210, 9773776, 17051221, 23302862, 32296183
GO:0042802	Molecular function	Identical protein binding	IPI	17472440, 20738396, 22854022, 23106816, 23416304, 23510797

Protein Information

Protein Name

Insulin, preproinsulin, proinsulin

Function

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver

Refseq Proteins

NP_000198.1, NP_001172026.1, NP_001172027.1, NP_001278826.1

UniProt

P01308

PDB

1A7F, 1AI0, 1AIY, 1B9E, 1BEN, 1EFE, 1EV3, 1EV6, 1EVR, 1FU2, 1FUB, 1G7A, 1G7B, 1GUJ, 1HIQ, 1HIS, 1HIT, 1HLS, 1HTV, 1HUI, 1IOG, 1IOH, 1J73, 1JCA, 1JCO, 1JK8, 1K3M, 1KMF, 1LKQ, 1LPH, 1MHI, 1MHJ, 1MSO, 1OS3, 1OS4, 1Q4V, 1QIY, 1QIZ, 1QJ0, 1RWE, 1SF1, 1SJT, 1SJU, 1T0C, 1T1K, 1T1P, 1T1Q, 1TRZ, 1TYL, 1TYM, 1UZ9