Enrichment analyses of diseases and pathways associated with precocious puberty using PrecocityDB

Gene Information

Gene Symbol

INSM1

Aliases

IA-1, IA1

Entrez Gene ID

3642

Gene Name

INSM transcriptional repressor 1

Chromosomal Location

20p11.23

HGNC ID

6090

Summary

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008]

e!Ensembl

Gene	ENSG00000173404
Transcript	ENST00000310227
Protein	ENSP00000312631

Gene Ontology (GO)

Show/Hide all(19 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000122	Biological process	Negative regulation of transcription by RNA polymerase II	IBA	21873635
GO:0000122	Biological process	Negative regulation of transcription by RNA polymerase II	IDA	11842116, 16569215, 18417529, 19124461
GO:0001933	Biological process	Negative regulation of protein phosphorylation	IDA	19124461
GO:0008285	Biological process	Negative regulation of cell proliferation	IDA	19124461
GO:0010564	Biological process	Regulation of cell cycle process	IBA	21873635
GO:0030182	Biological process	Neuron differentiation	IBA	21873635
GO:0043254	Biological process	Regulation of protein complex assembly	IDA	19124461
GO:0060290	Biological process	Transdifferentiation	IDA	16511571
GO:0071158	Biological process	Positive regulation of cell cycle arrest	IDA	19124461
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0017053	Cellular component	Transcriptional repressor complex	IBA	21873635
GO:0017053	Cellular component	Transcriptional repressor complex	IDA	16569215, 18417529
GO:0000978	Molecular function	RNA polymerase II proximal promoter sequence-specific DNA binding	IDA	11842116, 16569215, 18417529
GO:0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA	21873635
GO:0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	16569215
GO:0003700	Molecular function	DNA-binding transcription factor activity	IDA	11842116, 16569215, 18417529
GO:0030332	Molecular function	Cyclin binding	IPI	16569215, 18417529, 19124461
GO:0031490	Molecular function	Chromatin DNA binding	IDA	16569215, 18417529
GO:0042826	Molecular function	Histone deacetylase binding	IPI	16569215, 18417529

Protein Information

Protein Name

Insulinoma-associated protein 1, insulinoma-associated 1, zinc finger protein IA-1

Function

UniProt

Q01101

PDB

2LV2, 3ZMS