Enrichment analyses of diseases and pathways associated with precocious puberty using PrecocityDB

Gene Information

Gene Symbol

NPVF

Aliases

C7orf9, RFRP

Entrez Gene ID

64111

Gene Name

Neuropeptide VF precursor

Chromosomal Location

7p15.3

HGNC ID

13782

e!Ensembl

Gene	ENSG00000105954
Transcript	ENST00000222674
Protein	ENSP00000222674

SNPs

SNP	SNP ID	Associated disease	References
p.P128= ,rs2717851	rs2717851	Central Precocious Puberty (CPP)	25180599

Gene Ontology (GO)

Show/Hide all(6 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007218	Biological process	Neuropeptide signaling pathway	IBA	21873635
GO:0007218	Biological process	Neuropeptide signaling pathway	NAS	11025660
GO:0032277	Biological process	Negative regulation of gonadotropin secretion	IBA	21873635
GO:0032277	Biological process	Negative regulation of gonadotropin secretion	IDA	20027225
GO:0005102	Molecular function	Signaling receptor binding	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	32296183

Protein Information

Protein Name

Pro-FMRFamide-related neuropeptide VF, FMRFamide-related peptide, FMRFamide-related peptides, RFamide-related peptide, neuropeptide NPVF

Function

Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP, but RFRP-2 shows no inhibitory activity. Neuropeptide RFRP-1 induces secretion of prolactin in rats. Neuropeptide NPVF blocks morphine-induced analgesia.

UniProt

Q9HCQ7