Enrichment analyses of diseases and pathways associated with precocious puberty using PrecocityDB

Gene Information

Gene Symbol

TACR3

Aliases

HH11, NK-3R, NK3, NK3R, NKR, TAC3R, TAC3RL

Entrez Gene ID

6870

Gene Name

Tachykinin receptor 3

Chromosomal Location

4q24

HGNC ID

11528

RefSeq DNA

NG_023344.1

RefSeq mRNA

NM_001059.2, NM_001059.3

e!Ensembl

Gene	ENSG00000169836
Transcript	ENST00000304883
Protein	ENSP00000303325

SNPs

SNP	SNP ID	Associated disease	References
rs17033889	rs17033889	Idiopathic precocious puberty	25153567
rs201437953	rs201437953	Idiopathic precocious puberty	25153567
rs111751295	rs111751295	Idiopathic precocious puberty	25153567
rs201151576	rs201151576	Idiopathic precocious puberty	25153567

Gene Ontology (GO)

Show/Hide all(9 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007217	Biological process	Tachykinin receptor signaling pathway	TAS	8990205
GO:1902093	Biological process	Positive regulation of flagellated sperm motility	IBA	21873635
GO:1902093	Biological process	Positive regulation of flagellated sperm motility	IMP	17437961
GO:0005886	Cellular component	Plasma membrane	IBA	21873635
GO:0005887	Cellular component	Integral component of plasma membrane	TAS	1374246
GO:0097225	Cellular component	Sperm midpiece	IBA	21873635
GO:0097225	Cellular component	Sperm midpiece	IDA	17437961
GO:0004995	Molecular function	Tachykinin receptor activity	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	12716968, 23597562

Protein Information

Protein Name

Neuromedin-K receptor, NK-3 receptor, NK3 receptor, neurokinin B receptor, neurokinin beta receptor

Function

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P

Refseq Proteins

NP_001050.1

UniProt

P29371